Tuesday, October 07, 2008

Duke University and Seroquel XR for Social Anxiety Disorder

Duke University is conducting many clinical trials on mental health, neuroscience and neurological disorders.

1)Quetiapine XR for Social Anxiety Disorder

The purpose of this study is to examine:
  • The short- and long-term effectiveness and tolerability of quetiapine XR for the treatment of social anxiety disorder (SAD)
  • The continuation effects of quetiapine XR in preventing SAD relapse
We are looking for subjects 18-65 years old.
The study consists of eight weeks of open-label treatment with quetiapine XR (50-400 mg/day). Those who show a minimal improvement will go into a 12-week period with either quetiapine XR or placebo.
There are total of 10 visits to Duke.
Subjects will be compensated up to $270 after the completion of the study.
For more information, contact Nabila Lateef at 919-684-9701.

2)Generalized Anxiety Disorder

The purpose of this trial is to find out if the study drug can be used to improve symptoms of generalized anxiety disorder. We are looking for subjects between 18 and 65 years old.
  • You will be taking the study drug, PD0332334, at a dose of 350 mg, 450 mg, or 600 mg, or a placebo.
  • Subjects cannot take antidepressants or antianxiety medications other than study drug during their participation.
  • The study lasts up to 10 weeks once enrolled and requires nine visits to Duke.
The study pays $45 per completed visit. This is paid after your last study visit
For more information, contact Nabila Lateef at 919-684-9701.

These are 8 of the 29 clinical trials that Duke University is doing:

New Drug for ADHD ; Project Activate II: 60 Years or Older and Feeling Down? ; Having Trouble Sleeping with Depression? ; Are You Sad or Blue and Do You Enjoy Things Less Than You Used To? this one will use paroxetine (Paxil/Seroxat/Aropax) and duloxetine (Cymbalta); Suffering From Bipolar Disorder? investigational drug ; Aripiprazole and Lamictal in Bipolar Depression ; Lexapro in Atypical Depression ; Are You Depressed? ;.....

and many others. After reading it I will try to volunteer for this last one of this list.
Can you understand why do they test the same drug over and over again?
Quetiapine (Seroquel) is already being used off-label for anxiety disorder and it would be a great help legitimize the use of these drugs. AstraZeneca will be very happy with the results.

Wow! Just found this:

Brain Donors Needed for Alzheimer's Disease Research

The Joseph and Kathleen Bryan Alzheimer's Disease Research Center at Duke needs brain donors who:
  • Are at least 65 years old
  • Have no memory problems
  • Are willing to have yearly memory and neurological assessments in their home
  • Live within one hour of Duke

Enrollment in the Autopsy and Brain Donation Program must be made well in advance of death.
For more information, contact Mari Szymanski, RN,C, at 1-866-444-2372 or 919-668-1908.

I would donate if a research would really help and in my case it would be the effects that psych drugs causes to the brain.
Why don't they start this kind of research since there are already suspicions that some of these drugs can change the brain size? There are evidences that SSRIs, based on patients' reports that these drugs have caused cognitive impairments, sexual problems that persists after quitting - a condition known as PSSD - violent behavior and other side effects and the withdrawal syndrome is still not recognized as a problem.
Many questions I have will not be answered in my lifetime.


Stephany said...

Great information Ana! I cannot imagine Seroquel XR for anxiety! I could barely wake up 14 hrs after taking it, --I'd rather have anxiety!

Ana said...

I believe that's the idea!
Instead of anxiety, sleep.
I've started feeling more and more anxious after I start some drugs.
Thank you!

Anonymous said...

My husband is in this drug trial. I was as surprised as you are, Stephany, when I heard they were using Seroquel. It has CHANGED HIS LIFE, though. For the first few days he was really sleepy (and cranky) but those side effects went away. He's not the pathologically shy guy he used to be that just quaked on the inside when he had to talk to people. I will forever be grateful to Duke -- they'll never know the impact this has made on our family.